Mantle cell lymphoma as a component of composite lymphoma: Clinicopathologic parameters and biologic implications

Journal Article (Journal Article)

Composite lymphoma is a rare circumstance in which 2 or more distinct types of lymphoma occur in a single anatomical location. Although composite lymphoma has been increasingly identified with the advent of molecular genetic techniques, this topic has only rarely been a specific focus of the medical scientific literature. In this review, we focus on mantle cell lymphoma occurring as a major pathologic component of composite lymphoma and emphasize the clinicopathologic features of these tumors and associated biologic implications. To date, 26 cases of composite lymphoma including a component of mantle cell lymphoma have been previously published. Issues of clonal relatedness between the individual lymphoma components and emerging biologic implications as well as potential diagnostic pitfalls are evaluated. © 2012 Elsevier Inc. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Papathomas, TG; Venizelos, I; Dunphy, CH; Said, JW; Wang, ML; Campo, E; Swerdlow, SH; Chan, JC; Bueso-Ramos, CE; Weisenburger, DD; Medeiros, LJ; Young, KH

Published Date

  • January 1, 2012

Published In

Volume / Issue

  • 43 / 4

Start / End Page

  • 467 - 480

Electronic International Standard Serial Number (EISSN)

  • 1532-8392

International Standard Serial Number (ISSN)

  • 0046-8177

Digital Object Identifier (DOI)

  • 10.1016/j.humpath.2011.08.024

Citation Source

  • Scopus