Role of macrophage migration inhibitory factor in age-related lung disease.

Journal Article (Journal Article;Review)

The prevalence of many common respiratory disorders, including pneumonia, chronic obstructive lung disease, pulmonary fibrosis, and lung cancer, increases with age. Little is known of the host factors that may predispose individuals to such diseases. Macrophage migration inhibitory factor (MIF) is a potent upstream regulator of the immune system. MIF is encoded by variant alleles that occur commonly in the population. In addition to its role as a proinflammatory cytokine, a growing body of literature demonstrates that MIF influences diverse molecular processes important for the maintenance of cellular homeostasis and may influence the incidence or clinical manifestations of a variety of chronic lung diseases. This review highlights the biological properties of MIF and its implication in age-related lung disease.

Full Text

Duke Authors

Cited Authors

  • Sauler, M; Bucala, R; Lee, PJ

Published Date

  • July 1, 2015

Published In

Volume / Issue

  • 309 / 1

Start / End Page

  • L1 - 10

PubMed ID

  • 25957294

Pubmed Central ID

  • PMC4491511

Electronic International Standard Serial Number (EISSN)

  • 1522-1504

Digital Object Identifier (DOI)

  • 10.1152/ajplung.00339.2014


  • eng

Conference Location

  • United States