Pathways of cell signaling in hyperoxia.

Journal Article (Journal Article;Review)

Administration of high concentrations of oxygen (hyperoxia) is a mainstay of supportive treatment for patients suffering from severe respiratory failure. However, hyperoxia, by generating excess systemic reactive oxygen species (ROS), can exacerbate organ failure by causing cellular injury. Therefore, a better understanding of the signal transduction pathways in hyperoxia may provide the basis for effective therapeutic interventions. The major biological effects of hyperoxia include cell death, induction of stress responses, inflammation, and modulation of cell growth. Major signaling pathways that appear to be involved include the mitogen-activated protein kinases (MAPKs), AP-1, and NF-kappa B, which converge, ultimately, to the expression of a range of stress response genes, cytokines, and growth factors.

Full Text

Duke Authors

Cited Authors

  • Lee, PJ; Choi, AMK

Published Date

  • August 15, 2003

Published In

Volume / Issue

  • 35 / 4

Start / End Page

  • 341 - 350

PubMed ID

  • 12899937

International Standard Serial Number (ISSN)

  • 0891-5849

Digital Object Identifier (DOI)

  • 10.1016/s0891-5849(03)00279-x


  • eng

Conference Location

  • United States