Cotransfection of heme oxygenase-1 prevents the acute inflammation elicited by a second adenovirus.

Journal Article (Journal Article)

The acute inflammatory response elicited by adenovirus vectors results in loss of gene expression and tissue injury in the target organ. This acute inflammation is now believed to be the major limiting factor for the use of adenovirus vectors in gene therapy. While exploring the level of acute inflammation caused by the adenovirus encoding the gene for the anti-inflammatory enzyme heme oxygenase-1, we discovered that this adenovirus not only did not elicit acute inflammation, but could prevent the inflammation caused by a second adenovirus. Here we describe a new approach to gene therapy, which uses the encoding of the potent anti-inflammatory enzyme heme oxygenase-1 to prevent early host inflammatory responses normally associated with adenovirus vectors.

Full Text

Duke Authors

Cited Authors

  • McCarter, SD; Scott, JR; Lee, PJ; Zhang, X; Choi, AMK; McLean, CA; Badhwar, A; Dungey, AA; Bihari, A; Harris, KA; Potter, RF

Published Date

  • September 2003

Published In

Volume / Issue

  • 10 / 19

Start / End Page

  • 1629 - 1635

PubMed ID

  • 12923561

International Standard Serial Number (ISSN)

  • 0969-7128

Digital Object Identifier (DOI)

  • 10.1038/sj.gt.3302063

Language

  • eng

Conference Location

  • England