Design of therapeutic biomaterials to control inflammation.

Journal Article (Journal Article;Review)

Inflammation plays an important role in the response to danger signals arising from damage to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in many diseases, including cancer, sepsis and autoimmunity. The efficacy of anti-inflammatory drugs, developed for the treatment of dysregulated inflammation, can be potentiated using biomaterials, by improving the bioavailability of drugs and by reducing side effects. In this Review, we first outline key elements and stages of the inflammatory environment and then discuss the design of biomaterials for different anti-inflammatory therapeutic strategies. Biomaterials can be engineered to scavenge danger signals, such as reactive oxygen and nitrogen species and cell-free DNA, in the early stages of inflammation. Materials can also be designed to prevent adhesive interactions of leukocytes and endothelial cells that initiate inflammatory responses. Furthermore, nanoscale platforms can deliver anti-inflammatory agents to inflammation sites. We conclude by discussing the challenges and opportunities for biomaterial innovations in addressing inflammation.

Full Text

Duke Authors

Cited Authors

  • Tu, Z; Zhong, Y; Hu, H; Shao, D; Haag, R; Schirner, M; Lee, J; Sullenger, B; Leong, KW

Published Date

  • 2022

Published In

Volume / Issue

  • 7 / 7

Start / End Page

  • 557 - 574

PubMed ID

  • 35251702

Pubmed Central ID

  • PMC8884103

International Standard Serial Number (ISSN)

  • 2058-8437

Digital Object Identifier (DOI)

  • 10.1038/s41578-022-00426-z

Language

  • eng

Conference Location

  • England