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An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis.

Publication ,  Journal Article
Belina, ME; Kwock, JT; Al-Rohil, R; Fresco, A
Published in: Am J Dermatopathol
July 1, 2022

Indeterminant cell histiocytosis (ICH) is a rare lymphoproliferative disorder that demonstrates features of Langerhans and non-Langerhans cell histiocytoses and diagnosis can be challenging. We present a case of a 62 year old woman with a generalized eruption of erythematous papules on the face, trunk and extremities. Skin biopsies demonstrated a dermal mononuclear cell infiltrate with monocytic (CD4, CD33), histiocytic (CD68, CD163), and dendritic cell (CD1a) immunophenotype but negative for Langerhans' cell marker (CD207). The differential diagnosis included leukemia cutis and ICH, and further workup revealed a normal bone marrow biopsy. To confirm the diagnosis of ICH, next generation sequencing with ETV3-NCOA2 gene fusion was performed and was positive. The patient's condition improved with methotrexate and narrow band UVB phototherapy. Our case adds to the existing literature supporting the use of next-generation sequencing to test for ETV3-NCOA2 gene fusion in suspected cases of ICH.

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Published In

Am J Dermatopathol

DOI

EISSN

1533-0311

Publication Date

July 1, 2022

Volume

44

Issue

7

Start / End Page

529 / 531

Location

United States

Related Subject Headings

  • Skin
  • Middle Aged
  • Humans
  • Histiocytosis, Non-Langerhans-Cell
  • Histiocytosis, Langerhans-Cell
  • Histiocytosis
  • Histiocytes
  • High-Throughput Nucleotide Sequencing
  • Female
  • Dermatology & Venereal Diseases
 

Citation

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Belina, M. E., Kwock, J. T., Al-Rohil, R., & Fresco, A. (2022). An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis. Am J Dermatopathol, 44(7), 529–531. https://doi.org/10.1097/DAD.0000000000002167
Belina, Morgan E., Jeffery T. Kwock, Rami Al-Rohil, and Amber Fresco. “An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis.Am J Dermatopathol 44, no. 7 (July 1, 2022): 529–31. https://doi.org/10.1097/DAD.0000000000002167.
Belina ME, Kwock JT, Al-Rohil R, Fresco A. An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis. Am J Dermatopathol. 2022 Jul 1;44(7):529–31.
Belina, Morgan E., et al. “An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis.Am J Dermatopathol, vol. 44, no. 7, July 2022, pp. 529–31. Pubmed, doi:10.1097/DAD.0000000000002167.
Belina ME, Kwock JT, Al-Rohil R, Fresco A. An Atypical Myelomonocytic Cell Infiltrate: Use of Next-Generation Sequencing to Diagnose Indeterminate Cell Histiocytosis. Am J Dermatopathol. 2022 Jul 1;44(7):529–531.

Published In

Am J Dermatopathol

DOI

EISSN

1533-0311

Publication Date

July 1, 2022

Volume

44

Issue

7

Start / End Page

529 / 531

Location

United States

Related Subject Headings

  • Skin
  • Middle Aged
  • Humans
  • Histiocytosis, Non-Langerhans-Cell
  • Histiocytosis, Langerhans-Cell
  • Histiocytosis
  • Histiocytes
  • High-Throughput Nucleotide Sequencing
  • Female
  • Dermatology & Venereal Diseases