Characterization of low-grade arthralgia, myalgia, and musculoskeletal pain with ibrutinib therapy: pooled analysis of clinical trials in patients with chronic lymphocytic leukemia and mantle cell lymphoma.

Journal Article (Clinical Trial;Journal Article)

Joint and muscle pain, including arthralgia, myalgia, and musculoskeletal pain, are among the common adverse events (AEs) reported for ibrutinib, a once-daily Bruton's tyrosine kinase inhibitor approved for the treatment of various B-cell malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). This pooled analysis from nine clinical trials of ibrutinib in CLL and MCL (N = 1178) evaluated patterns of these AEs. Any grade arthralgia, myalgia, and musculoskeletal pain occurred in 18%, 10%, and 6% of patients, respectively. AEs were primarily low-grade (grade 1/2: 97‒99%) and occurred during the first year of treatment; most resolved (67%-80%) at first occurrence. Few (<5%) patients required ibrutinib dose modification; no patients discontinued ibrutinib due to these AEs. Among patients evaluated for concomitant medication use, all those receiving concomitant medications after the first AE occurrence experienced AE resolution. These data suggest that these AEs were not treatment-limiting during ibrutinib therapy.

Full Text

Duke Authors

Cited Authors

  • Siddiqi, T; Coutre, S; McKinney, M; Barr, PM; Rogers, K; Mokatrin, A; Valentino, R; Szoke, A; Deshpande, S; Zhu, A; Arango-Hisijara, I; Osei-Bonsu, K; Wang, M; O'Brien, S

Published Date

  • July 2022

Published In

Volume / Issue

  • 63 / 7

Start / End Page

  • 1580 - 1588

PubMed ID

  • 35227147

Electronic International Standard Serial Number (EISSN)

  • 1029-2403

Digital Object Identifier (DOI)

  • 10.1080/10428194.2022.2038372


  • eng

Conference Location

  • United States