Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy.

Journal Article (Journal Article)

PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to be trafficked into neurites, local translation is required for this mitophagy pathway to be active far from the soma. The Pink1 transcript is associated and cotransported with neuronal mitochondria. In concert with translation, the mitochondrial outer membrane proteins synaptojanin 2 binding protein (SYNJ2BP) and synaptojanin 2 (SYNJ2) are required for tethering Pink1 mRNA to mitochondria via an RNA-binding domain in SYNJ2. This neuron-specific adaptation for the local translation of PINK1 provides distal mitochondria with a continuous supply of PINK1 for the activation of mitophagy.

Full Text

Duke Authors

Cited Authors

  • Harbauer, AB; Hees, JT; Wanderoy, S; Segura, I; Gibbs, W; Cheng, Y; Ordonez, M; Cai, Z; Cartoni, R; Ashrafi, G; Wang, C; Perocchi, F; He, Z; Schwarz, TL

Published Date

  • May 4, 2022

Published In

Volume / Issue

  • 110 / 9

Start / End Page

  • 1516 - 1531.e9

PubMed ID

  • 35216662

Pubmed Central ID

  • PMC9081165

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2022.01.035

Language

  • eng

Conference Location

  • United States