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Transitional premonocytes emerge in the periphery for host defense against bacterial infections.

Publication ,  Journal Article
Teh, YC; Chooi, MY; Liu, D; Kwok, I; Lai, GC; Ayub Ow Yong, L; Ng, M; Li, JLY; Tan, Y; Evrard, M; Tan, L; Liong, KH; Leong, K; Goh, CC ...
Published in: Sci Adv
March 4, 2022

Circulating Ly6Chi monocytes often undergo cellular death upon exhaustion of their antibacterial effector functions, which limits their capacity for subsequent macrophage differentiation. This shrouds the understanding on how the host replaces the tissue-resident macrophage niche effectively during bacterial invasion to avert infection morbidity. Here, we show that proliferating transitional premonocytes (TpMos), an immediate precursor of mature Ly6Chi monocytes (MatMos), were mobilized into the periphery in response to acute bacterial infection and sepsis. TpMos were less susceptible to apoptosis and served as the main source of macrophage replenishment when MatMos were vulnerable toward bacteria-induced cellular death. Furthermore, TpMo and its derived macrophages contributed to host defense by balancing the proinflammatory cytokine response of MatMos. Consequently, adoptive transfer of TpMos improved the survival outcome of lethal sepsis. Our findings hence highlight a protective role for TpMos during bacterial infections and their contribution toward monocyte-derived macrophage heterogeneity in distinct disease outcomes.

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Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

March 4, 2022

Volume

8

Issue

9

Start / End Page

eabj4641

Location

United States

Related Subject Headings

  • Sepsis
  • Monocytes
  • Mice, Inbred C57BL
  • Mice
  • Macrophages
  • Humans
  • Cytokines
  • Bacterial Infections
  • Animals
 

Citation

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Teh, Y. C., Chooi, M. Y., Liu, D., Kwok, I., Lai, G. C., Ayub Ow Yong, L., … Chong, S. Z. (2022). Transitional premonocytes emerge in the periphery for host defense against bacterial infections. Sci Adv, 8(9), eabj4641. https://doi.org/10.1126/sciadv.abj4641
Teh, Ye Chean, Ming Yao Chooi, Dehua Liu, Immanuel Kwok, Ghee Chuan Lai, Liyana Ayub Ow Yong, Melissa Ng, et al. “Transitional premonocytes emerge in the periphery for host defense against bacterial infections.Sci Adv 8, no. 9 (March 4, 2022): eabj4641. https://doi.org/10.1126/sciadv.abj4641.
Teh YC, Chooi MY, Liu D, Kwok I, Lai GC, Ayub Ow Yong L, et al. Transitional premonocytes emerge in the periphery for host defense against bacterial infections. Sci Adv. 2022 Mar 4;8(9):eabj4641.
Teh, Ye Chean, et al. “Transitional premonocytes emerge in the periphery for host defense against bacterial infections.Sci Adv, vol. 8, no. 9, Mar. 2022, p. eabj4641. Pubmed, doi:10.1126/sciadv.abj4641.
Teh YC, Chooi MY, Liu D, Kwok I, Lai GC, Ayub Ow Yong L, Ng M, Li JLY, Tan Y, Evrard M, Tan L, Liong KH, Leong K, Goh CC, Chan AYJ, Shadan NB, Mantri CK, Hwang YY, Cheng H, Cheng T, Yu W, Tey HL, Larbi A, St John A, Angeli V, Ruedl C, Lee B, Ginhoux F, Chen SL, Ng LG, Ding JL, Chong SZ. Transitional premonocytes emerge in the periphery for host defense against bacterial infections. Sci Adv. 2022 Mar 4;8(9):eabj4641.

Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

March 4, 2022

Volume

8

Issue

9

Start / End Page

eabj4641

Location

United States

Related Subject Headings

  • Sepsis
  • Monocytes
  • Mice, Inbred C57BL
  • Mice
  • Macrophages
  • Humans
  • Cytokines
  • Bacterial Infections
  • Animals