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Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review.

Publication ,  Journal Article
Kakos, CD; Ziogas, IA; Demiri, CD; Esagian, SM; Economopoulos, KP; Moris, D; Tsoulfas, G; Alexopoulos, SP
Published in: Cancers
March 2022

Liver transplantation (LT) is the only potentially curative option for children with unresectable hepatocellular carcinoma (HCC). We performed a systematic review of the MEDLINE, Scopus, Cochrane Library, and Web of Science databases (end-of-search date: 31 July 2020). Our outcomes were overall survival (OS) and disease-free survival (DFS). We evaluated the effect of clinically relevant variables on outcomes using the Kaplan-Meier method and log-rank test. Sixty-seven studies reporting on 245 children undergoing LT for HCC were included. DFS data were available for 150 patients and the 1-, 3-, and 5-year DFS rates were 92.3%, 89.1%, and 84.5%, respectively. Sixty of the two hundred and thirty-eight patients (25.2%) died over a mean follow up of 46.8 ± 47.4 months. OS data were available for 222 patients and the 1-, 3-, and 5-year OS rates were 87.9%, 78.8%, and 74.3%, respectively. Although no difference was observed between children transplanted within vs. beyond Milan criteria (p = 0.15), superior OS was observed in children transplanted within vs. beyond UCSF criteria (p = 0.02). LT can yield favorable outcomes for pediatric HCC beyond Milan but not beyond UCSF criteria. Further research is required to determine appropriate LT selection criteria for pediatric HCC.

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Published In

Cancers

DOI

EISSN

2072-6694

ISSN

2072-6694

Publication Date

March 2022

Volume

14

Issue

5

Start / End Page

1294

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Kakos, C. D., Ziogas, I. A., Demiri, C. D., Esagian, S. M., Economopoulos, K. P., Moris, D., … Alexopoulos, S. P. (2022). Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review. Cancers, 14(5), 1294. https://doi.org/10.3390/cancers14051294
Kakos, Christos D., Ioannis A. Ziogas, Charikleia D. Demiri, Stepan M. Esagian, Konstantinos P. Economopoulos, Dimitrios Moris, Georgios Tsoulfas, and Sophoclis P. Alexopoulos. “Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review.Cancers 14, no. 5 (March 2022): 1294. https://doi.org/10.3390/cancers14051294.
Kakos CD, Ziogas IA, Demiri CD, Esagian SM, Economopoulos KP, Moris D, et al. Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review. Cancers. 2022 Mar;14(5):1294.
Kakos, Christos D., et al. “Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review.Cancers, vol. 14, no. 5, Mar. 2022, p. 1294. Epmc, doi:10.3390/cancers14051294.
Kakos CD, Ziogas IA, Demiri CD, Esagian SM, Economopoulos KP, Moris D, Tsoulfas G, Alexopoulos SP. Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review. Cancers. 2022 Mar;14(5):1294.

Published In

Cancers

DOI

EISSN

2072-6694

ISSN

2072-6694

Publication Date

March 2022

Volume

14

Issue

5

Start / End Page

1294

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis