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Brain-wide electrical dynamics encode individual appetitive social behavior.

Publication ,  Journal Article
Mague, SD; Talbot, A; Blount, C; Walder-Christensen, KK; Duffney, LJ; Adamson, E; Bey, AL; Ndubuizu, N; Thomas, GE; Hughes, DN; Grossman, Y ...
Published in: Neuron
May 18, 2022

The architecture whereby activity across many brain regions integrates to encode individual appetitive social behavior remains unknown. Here we measure electrical activity from eight brain regions as mice engage in a social preference assay. We then use machine learning to discover a network that encodes the extent to which individual mice engage another mouse. This network is organized by theta oscillations leading from prelimbic cortex and amygdala that converge on the ventral tegmental area. Network activity is synchronized with cellular firing, and frequency-specific activation of a circuit within this network increases social behavior. Finally, the network generalizes, on a mouse-by-mouse basis, to encode individual differences in social behavior in healthy animals but fails to encode individual behavior in a 'high confidence' genetic model of autism. Thus, our findings reveal the architecture whereby the brain integrates distributed activity across timescales to encode an appetitive brain state underlying individual differences in social behavior.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

May 18, 2022

Volume

110

Issue

10

Start / End Page

1728 / 1741.e7

Location

United States

Related Subject Headings

  • Ventral Tegmental Area
  • Social Behavior
  • Neurology & Neurosurgery
  • Mice
  • Brain
  • Appetitive Behavior
  • Animals
  • Amygdala
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

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Mague, S. D., Talbot, A., Blount, C., Walder-Christensen, K. K., Duffney, L. J., Adamson, E., … Dzirasa, K. (2022). Brain-wide electrical dynamics encode individual appetitive social behavior. Neuron, 110(10), 1728-1741.e7. https://doi.org/10.1016/j.neuron.2022.02.016
Mague, Stephen D., Austin Talbot, Cameron Blount, Kathryn K. Walder-Christensen, Lara J. Duffney, Elise Adamson, Alexandra L. Bey, et al. “Brain-wide electrical dynamics encode individual appetitive social behavior.Neuron 110, no. 10 (May 18, 2022): 1728-1741.e7. https://doi.org/10.1016/j.neuron.2022.02.016.
Mague SD, Talbot A, Blount C, Walder-Christensen KK, Duffney LJ, Adamson E, et al. Brain-wide electrical dynamics encode individual appetitive social behavior. Neuron. 2022 May 18;110(10):1728-1741.e7.
Mague, Stephen D., et al. “Brain-wide electrical dynamics encode individual appetitive social behavior.Neuron, vol. 110, no. 10, May 2022, pp. 1728-1741.e7. Pubmed, doi:10.1016/j.neuron.2022.02.016.
Mague SD, Talbot A, Blount C, Walder-Christensen KK, Duffney LJ, Adamson E, Bey AL, Ndubuizu N, Thomas GE, Hughes DN, Grossman Y, Hultman R, Sinha S, Fink AM, Gallagher NM, Fisher RL, Jiang Y-H, Carlson DE, Dzirasa K. Brain-wide electrical dynamics encode individual appetitive social behavior. Neuron. 2022 May 18;110(10):1728-1741.e7.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

May 18, 2022

Volume

110

Issue

10

Start / End Page

1728 / 1741.e7

Location

United States

Related Subject Headings

  • Ventral Tegmental Area
  • Social Behavior
  • Neurology & Neurosurgery
  • Mice
  • Brain
  • Appetitive Behavior
  • Animals
  • Amygdala
  • 5202 Biological psychology
  • 3209 Neurosciences