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Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis.

Publication ,  Journal Article
Soulsby, WD; Balmuri, N; Cooley, V; Gerber, LM; Lawson, E; Goodman, S; Onel, K; Mehta, B; CARRA Registry Investigators,
Published in: Pediatr Rheumatol Online J
March 7, 2022

BACKGROUND: Social determinants of health (SDH) greatly influence outcomes during the first year of treatment in rheumatoid arthritis, a disease similar to polyarticular juvenile idiopathic arthritis (pJIA). We investigated the correlation of community poverty level and other SDH with the persistence of moderate to severe disease activity and functional disability over the first year of treatment in pJIA patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry. METHODS: In this cohort study, unadjusted and adjusted generalized linear mixed effects models analyzed the effect of community poverty and other SDH on disease activity, using the clinical Juvenile Arthritis Disease Activity Score-10, and disability, using the Child Health Assessment Questionnaire, measured at baseline, 6, and 12 months. RESULTS: One thousand six hundred eighty-four patients were identified. High community poverty (≥20% living below the federal poverty level) was associated with increased odds of functional disability (OR 1.82, 95% CI 1.28-2.60) but was not statistically significant after adjustment (aOR 1.23, 95% CI 0.81-1.86) and was not associated with increased disease activity. Non-white race/ethnicity was associated with higher disease activity (aOR 2.48, 95% CI: 1.41-4.36). Lower self-reported household income was associated with higher disease activity and persistent functional disability. Public insurance (aOR 1.56, 95% CI 1.06-2.29) and low family education (aOR 1.89, 95% CI 1.14-3.12) was associated with persistent functional disability. CONCLUSION: High community poverty level was associated with persistent functional disability in unadjusted analysis but not with persistent moderate to high disease activity. Race/ethnicity and other SDH were associated with persistent disease activity and functional disability.

Duke Scholars

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Published In

Pediatr Rheumatol Online J

DOI

EISSN

1546-0096

Publication Date

March 7, 2022

Volume

20

Issue

1

Start / End Page

18

Location

England

Related Subject Headings

  • Social Determinants of Health
  • Retrospective Studies
  • Male
  • Humans
  • Female
  • Disability Evaluation
  • Correlation of Data
  • Cohort Studies
  • Child, Preschool
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
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Soulsby, W. D., Balmuri, N., Cooley, V., Gerber, L. M., Lawson, E., Goodman, S., … CARRA Registry Investigators, . (2022). Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis. Pediatr Rheumatol Online J, 20(1), 18. https://doi.org/10.1186/s12969-022-00676-9
Soulsby, William Daniel, Nayimisha Balmuri, Victoria Cooley, Linda M. Gerber, Erica Lawson, Susan Goodman, Karen Onel, Bella Mehta, and Bella CARRA Registry Investigators. “Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis.Pediatr Rheumatol Online J 20, no. 1 (March 7, 2022): 18. https://doi.org/10.1186/s12969-022-00676-9.
Soulsby WD, Balmuri N, Cooley V, Gerber LM, Lawson E, Goodman S, et al. Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis. Pediatr Rheumatol Online J. 2022 Mar 7;20(1):18.
Soulsby, William Daniel, et al. “Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis.Pediatr Rheumatol Online J, vol. 20, no. 1, Mar. 2022, p. 18. Pubmed, doi:10.1186/s12969-022-00676-9.
Soulsby WD, Balmuri N, Cooley V, Gerber LM, Lawson E, Goodman S, Onel K, Mehta B, CARRA Registry Investigators. Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis. Pediatr Rheumatol Online J. 2022 Mar 7;20(1):18.
Journal cover image

Published In

Pediatr Rheumatol Online J

DOI

EISSN

1546-0096

Publication Date

March 7, 2022

Volume

20

Issue

1

Start / End Page

18

Location

England

Related Subject Headings

  • Social Determinants of Health
  • Retrospective Studies
  • Male
  • Humans
  • Female
  • Disability Evaluation
  • Correlation of Data
  • Cohort Studies
  • Child, Preschool
  • Child