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Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer.

Publication ,  Journal Article
Sullivan, BA; Noujaim, M; Roper, J
Published in: Gastrointest Endosc Clin N Am
April 2022

Colorectal cancer is the second leading cause of cancer-associated mortality, with a lifetime risk of approximately 4% to 5%. Colorectal cancer develops from the sequential acquisition of defined genetic mutations in the colonic epithelium. Tumorigenesis from normal tissue to cancer occurs largely through 3 pathways: the chromosomal instability pathway, the microsatellite instability pathway, and the sessile serrated pathway. Colorectal cancer incidence and mortality have decreased by approximately 35% since the beginning of screening programs in the 1990s, although other factors such as use of aspirin for coronary disease prevention and decreased smoking rates may also be important. In this review, we discuss the etiology, epidemiology, and histology of colorectal polyps and cancer.

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Published In

Gastrointest Endosc Clin N Am

DOI

EISSN

1558-1950

Publication Date

April 2022

Volume

32

Issue

2

Start / End Page

177 / 194

Location

United States

Related Subject Headings

  • Humans
  • Gastroenterology & Hepatology
  • Colorectal Neoplasms
  • Colonic Polyps
  • Cell Transformation, Neoplastic
  • Adenoma
 

Citation

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ICMJE
MLA
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Sullivan, B. A., Noujaim, M., & Roper, J. (2022). Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer. Gastrointest Endosc Clin N Am, 32(2), 177–194. https://doi.org/10.1016/j.giec.2021.12.001
Sullivan, Brian A., Michael Noujaim, and Jatin Roper. “Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer.Gastrointest Endosc Clin N Am 32, no. 2 (April 2022): 177–94. https://doi.org/10.1016/j.giec.2021.12.001.
Sullivan BA, Noujaim M, Roper J. Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer. Gastrointest Endosc Clin N Am. 2022 Apr;32(2):177–94.
Sullivan, Brian A., et al. “Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer.Gastrointest Endosc Clin N Am, vol. 32, no. 2, Apr. 2022, pp. 177–94. Pubmed, doi:10.1016/j.giec.2021.12.001.
Sullivan BA, Noujaim M, Roper J. Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer. Gastrointest Endosc Clin N Am. 2022 Apr;32(2):177–194.
Journal cover image

Published In

Gastrointest Endosc Clin N Am

DOI

EISSN

1558-1950

Publication Date

April 2022

Volume

32

Issue

2

Start / End Page

177 / 194

Location

United States

Related Subject Headings

  • Humans
  • Gastroenterology & Hepatology
  • Colorectal Neoplasms
  • Colonic Polyps
  • Cell Transformation, Neoplastic
  • Adenoma