Role of stereotactic body radiotherapy in gynecologic radiation oncology.

Journal Article (Journal Article;Review)

Stereotactic body radiotherapy (SBRT, also referred to as stereotactic ablative radiotherapy (SABR)) has been used in the treatment of primary and metastatic solid tumors, and increasingly so in gynecologic oncology. This review article aims to summarize the current literature describing the utility of SBRT in the primary, recurrent, and limited metastatic settings for gynecologic malignancies. The use of SBRT in both retrospective and prospective reports has been associated with adequate control of the treated site, particularly in the setting of oligometastatic disease. It is not, however, recommended as an alternative to brachytherapy for intact disease unless all efforts to use brachytherapy are exhausted. While phase I and II trials have established the relative safety and potential toxicities of SBRT, there remains a dearth of phase III randomized evidence, including the use of immunotherapy, in order to better establish the role of this technique as a method of improving more global outcomes for our patients with gynecologic cancers.

Full Text

Duke Authors

Cited Authors

  • Shenker, R; Stephens, SJ; Davidson, B; Chino, J

Published Date

  • March 2022

Published In

Volume / Issue

  • 32 / 3

Start / End Page

  • 372 - 379

PubMed ID

  • 35256426

Electronic International Standard Serial Number (EISSN)

  • 1525-1438

Digital Object Identifier (DOI)

  • 10.1136/ijgc-2021-002466


  • eng

Conference Location

  • England