Type 1 Diabetes Mellitus.

Journal Article (Journal Article;Review)

Type 1 diabetes mellitus (T1DM) is an endocrine disorder in which pancreatic β cells stop producing insulin, typically due to autoimmune destruction. This results in hyperglycemia and ketosis; thus, insulin replacement is vital to management. Incidence peaks in puberty and early adulthood, but onset can occur at any age. However, prevalence is highest among adults because persons with T1DM live for many years. Symptoms include polyuria, polydipsia, and weight loss. Acute complications include diabetic ketoacidosis, which requires urgent management. Long-term complications include microvascular and macrovascular disease. Patients with T1DM are at higher risk for other autoimmune diseases and psychosocial issues. Management should focus on optimizing glucose control to reduce acute and long-term complications.

Full Text

Duke Authors

Cited Authors

  • Syed, FZ

Published Date

  • March 2022

Published In

Volume / Issue

  • 175 / 3

Start / End Page

  • ITC33 - ITC48

PubMed ID

  • 35254878

Electronic International Standard Serial Number (EISSN)

  • 1539-3704

Digital Object Identifier (DOI)

  • 10.7326/AITC202203150


  • eng

Conference Location

  • United States