Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus.

Journal Article (Journal Article;Review)

Congenital hydrocephalus occurs in one in 500-1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pressure hydrocephalus. Irrespective of its prevalence and significant impact on quality of life, neurosurgeons still rely on invasive cerebrospinal fluid shunt systems for the treatment of hydrocephalus that are exceptionally prone to failure and/or infection. Further understanding of this process at a molecular level, therefore, may have profound implications for improving treatment and quality of life for millions of individuals worldwide. The purpose of this article is to review the current research landscape on hydrocephalus with a focus on recent advances in our understanding of cerebrospinal fluid pathways from an evolutionary, genetics and molecular perspective.

Full Text

Duke Authors

Cited Authors

  • Bramall, AN; Anton, ES; Kahle, KT; Fecci, PE

Published Date

  • April 2022

Published In

Volume / Issue

  • 78 /

Start / End Page

  • 103931 -

PubMed ID

  • 35306341

Pubmed Central ID

  • PMC8933686

Electronic International Standard Serial Number (EISSN)

  • 2352-3964

Digital Object Identifier (DOI)

  • 10.1016/j.ebiom.2022.103931


  • eng

Conference Location

  • Netherlands