A controlled study of cellular immune function in affective disorders before and during somatic therapy.

Journal Article (Journal Article)

Lymphocyte blastogenesis induced by lectins (PHA, Con A, and PWM) was assessed in 27 drug-free patients with unipolar (n = 21) or bipolar (n = 5) depression and 13 normal controls. Fifteen patients were restudied after clinical remission. Symptomatic patients did not differ from controls nor did endogenous and nonendogenous depressions differ in their lymphocyte blastogenesis response to any of the three lectins. However, a significant reduction in lymphocyte blastogenesis with both PHA and Con A stimulation was found following somatic treatment. Cellular immune function appears to be normal in depressed patients, although the somatic therapies are associated with a reduction in this function.

Full Text

Duke Authors

Cited Authors

  • Albrecht, J; Helderman, JH; Schlesser, MA; Rush, AJ

Published Date

  • July 1985

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 185 - 193

PubMed ID

  • 3875872

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0165-1781(85)90075-7


  • eng

Conference Location

  • Ireland