Plasma GABA in mood disorders.

Conference Paper

Plasma levels of gamma-aminobutyric acid (GABA) were determined in 68 healthy controls and in 133 patients with mood disorder. Plasma GABA levels were significantly lower in the patients with mood disorder compared to controls. Levels of plasma GABA were similar among diagnostic groups (primary unipolar depression, bipolar depression, mania, and secondary depression). No differences in plasma GABA were found in patients classified according to family history, nor were any correlations found between plasma GABA levels and severity of depression as determined by the 17-item Hamilton Rating Scale for Depression. These findings support the notion that low plasma GABA may represent a biological marker for mood disorder.

Full Text

Duke Authors

Cited Authors

  • Petty, F; Kramer, GL; Dunnam, D; Rush, AJ

Published Date

  • 1990

Published In

Volume / Issue

  • 26 / 2

Start / End Page

  • 157 - 161

PubMed ID

  • 2236451

International Standard Serial Number (ISSN)

  • 0048-5764

Conference Location

  • United States