Persistent cortisol non-suppression after clinical recovery predicts symptomatic relapse in unipolar depression.

Journal Article (Journal Article)

We assessed the length and the quality of remission of 13 unipolar endogenous depressed patients, DST non-suppressors before treatment, in a 2-year prospective study. During this period, we recorded stressful life events. Persistent dexamethasone non-suppression, after treatment and complete clinical recovery, correlated highly with early clinical relapse. All six non-normalizers but only one normalizer were rehospitalized within the following 2 years for a major depressive relapse. Persistent DST non-suppression was unrelated to any impact of drug discontinuation, the occurrence of stressful life events or the length of illness-free intervals in the patient's prior course of illness. Persistent DST non-suppression appears to have significant prognostic value.

Full Text

Duke Authors

Cited Authors

  • Charles, GA; Schittecatte, M; Rush, AJ; Panzer, M; Wilmotte, J

Published Date

  • 1989

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 271 - 278

PubMed ID

  • 2529296

International Standard Serial Number (ISSN)

  • 0165-0327

Digital Object Identifier (DOI)

  • 10.1016/0165-0327(89)90010-4


  • eng

Conference Location

  • Netherlands