Which endogenous depressive symptoms relate to REM latency reduction?

Journal Article (Journal Article)

In most research dealing with biological abnormalities in depression, the clinical diagnosis of depression is made and the occurrence of a biological abnormality, for example, reduced REM latency, is documented. In this study, that design was reversed; REM latency was used as a grouping variable to assess empirically the "biological" priority of Research Diagnostic Criteria endogenous symptoms. We found that terminal insomnia, pervasive anhedonia, unreactive mood, and appetite loss were most likely to discriminate among "reduced" and "nonreduced" REM latency depressions at various threshold values. Contrary to expectation, diurnal mood variation was found equivalently in all categories of REM latency studied. Implications for clinical decision making based on endogenous symptoms are discussed.

Full Text

Duke Authors

Cited Authors

  • Giles, DE; Roffwarg, HP; Schlesser, MA; Rush, AJ

Published Date

  • May 1, 1986

Published In

Volume / Issue

  • 21 / 5-6

Start / End Page

  • 473 - 482

PubMed ID

  • 3697437

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(86)90189-7


  • eng

Conference Location

  • United States