A review of vagus nerve stimulation for treatment-resistant depression

Journal Article (Journal Article)

Vagus nerve stimulation (VNS), delivered by an implantable, programmable pulse generator (Cyberonics, Inc, Houston, TX), is effective in reducing the frequency, duration, and/or intensity of seizures in patients with treatment-resistant partial-onset seizures. The use of VNS as a potential treatment for psychiatric disorders is of particular interest given the known neuroanatomic and neurochemical effects of VNS. The first study of VNS for a psychiatric indication reported positive, although preliminary, results in a cohort of 30 patients with treatment-resistant depressive episodes treated openly (A. J. Rush, M. S. George, H. A. Sackeim, et al., Biol Psychiatry 2000;47:276-86). This article reviews the rationale and initial data regarding the use of VNS as a novel treatment for depression. © 2001 Academic Press.

Full Text

Duke Authors

Cited Authors

  • Marangell, LB; Rush, AJ; George, MS; Georges, D; Sackeim, HA

Published Date

  • January 1, 2001

Published In

Volume / Issue

  • 2 / 3 SUPPL. 3

International Standard Serial Number (ISSN)

  • 1525-5050

Digital Object Identifier (DOI)

  • 10.1006/ebeh.2001.0209

Citation Source

  • Scopus