An open-label trial of quetiapine for antipsychotic-induced sexual dysfunction.

Journal Article (Clinical Trial;Journal Article)

This study evaluated the effect of switching outpatients with schizophrenia and antipsychotic-induced sexual dysfunction to open-label quetiapine treatment. Secondary objectives were to compare the antipsychotic and prolactin-related effects of quetiapine versus prestudy antipsychotic treatment. Eight patients with at least moderately severe antipsychotic-induced sexual dysfunction (N = 7 taking risperidone, 4-6 mg/d; N = 1 taking haloperidol, 10 mg/d) were evaluated prospectively after they switched to 6 weeks of quetiapine treatment. The assessments that we used included evaluations of sexual functioning (Arizona Sexual Experience Scale [ASEX]; McGahuey et al., 2000), psychopathology (Positive and Negative Syndrome Scale [PANSS]; Kay, Fiszbeinm, & Opler, 1997), adverse events, and plasma prolactin levels. Quetiapine was associated with clinically and statistically significant improvement in ASEX total scores (p = 0.008) and significantly decreased PANSS total scores (p = 0.03). Plasma prolactin levels tended to decrease after the transition to quetiapine (p = 0.09). Quetiapine appears to offer an option to reduce antipsychotic-induced sexual dysfunction for outpatients with schizophrenia.

Full Text

Duke Authors

Cited Authors

  • Byerly, MJ; Lescouflair, E; Weber, MT; Bugno, RM; Fisher, R; Carmody, T; Varghese, F; Rush, AJ

Published Date

  • 2004

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 325 - 332

PubMed ID

  • 15672600

International Standard Serial Number (ISSN)

  • 0092-623X

Digital Object Identifier (DOI)

  • 10.1080/00926230490465082

Language

  • eng

Conference Location

  • England