Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder.

Journal Article (Journal Article)

OBJECTIVE: Presymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established. METHOD: This was a case-control genetic association study of HTT CAG allele size in two discovery cohorts of individuals with major depressive disorder and comparison subjects without major depression as well as a replication cohort of individuals with major depression and comparison subjects without major depression. RESULTS: CAG repeat lengths of 36 or greater were observed in six of 3,054 chromosomes from individuals with major depression, compared with none of 4,155 chromosomes from comparison subjects. In a third cohort, one expanded allele was observed among 1,202 chromosomes in the major depression group, compared with none of 2,678 chromosomes in comparison subjects. No clear pattern of clinical features was shared among individuals with the expanded repeats. CONCLUSIONS: In clinical populations of individuals diagnosed with major depression, approximately 3 in 1,000 carried expanded HTT CAG alleles.

Full Text

Duke Authors

Cited Authors

  • Perlis, RH; Smoller, JW; Mysore, J; Sun, M; Gillis, T; Purcell, S; Rietschel, M; Nöthen, MM; Witt, S; Maier, W; Iosifescu, DV; Sullivan, P; Rush, AJ; Fava, M; Breiter, H; Macdonald, M; Gusella, J

Published Date

  • May 2010

Published In

Volume / Issue

  • 167 / 5

Start / End Page

  • 574 - 579

PubMed ID

  • 20360314

Pubmed Central ID

  • PMC3114558

Electronic International Standard Serial Number (EISSN)

  • 1535-7228

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.2009.09070973


  • eng

Conference Location

  • United States