Changes in depressive symptoms and social functioning in the sequenced treatment alternatives to relieve depression study.

Journal Article (Clinical Trial;Journal Article)

Major depressive disorder (MDD) profoundly affects social functioning, including the ability to enjoy social activities with peers, friends, and family members. We sought to compare changes in social functioning and depressive symptoms in the first level of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Adult outpatients (N = 2876) with diagnoses of MDD were treated using flexible doses of citalopram for up to 14 weeks. We compared the change over the course of treatment in the social activities item of the Work and Social Adjustment Scale to the change in individual items of the Quick Inventory of Depressive Symptoms-Self-Rated (QIDS-SR). Improvement in social functioning was modestly positively correlated with improvement in sad mood, concentration/decision making, involvement, and energy/fatigability. Only 16% to 22% of the variance in the change in social functioning was accounted for by these symptoms, and only 32% was accounted for by the total QIDS-SR score. In this large real-world sample of outpatients treated using citalopram, changes in depressive symptoms do not entirely explain improvements in social functioning.

Full Text

Duke Authors

Cited Authors

  • Denninger, JW; van Nieuwenhuizen, AO; Wisniewski, SR; Luther, JF; Trivedi, MH; Rush, AJ; Gollan, JK; Pizzagalli, DA; Fava, M

Published Date

  • October 2011

Published In

Volume / Issue

  • 199 / 10

Start / End Page

  • 807 - 810

PubMed ID

  • 21964277

Electronic International Standard Serial Number (EISSN)

  • 1539-736X

Digital Object Identifier (DOI)

  • 10.1097/NMD.0b013e31822fcbe2


  • eng

Conference Location

  • United States