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A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.

Publication ,  Journal Article
Chen, JC; Kan, P; Yu, Z; Alrashdan, F; Garcia, R; Singer, A; Lai, CSE; Avants, B; Crosby, S; Li, Z; Wang, B; Felicella, MM; Robledo, A ...
Published in: Nat Biomed Eng
June 2022

Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals' sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.

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Published In

Nat Biomed Eng

DOI

EISSN

2157-846X

Publication Date

June 2022

Volume

6

Issue

6

Start / End Page

706 / 716

Location

England

Related Subject Headings

  • Wireless Technology
  • Swine
  • Sciatic Nerve
  • Rats
  • Prostheses and Implants
  • Proof of Concept Study
  • Electric Power Supplies
  • Animals
  • 4003 Biomedical engineering
 

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Chen, J. C., Kan, P., Yu, Z., Alrashdan, F., Garcia, R., Singer, A., … Robinson, J. T. (2022). A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves. Nat Biomed Eng, 6(6), 706–716. https://doi.org/10.1038/s41551-022-00873-7
Chen, Joshua C., Peter Kan, Zhanghao Yu, Fatima Alrashdan, Roberto Garcia, Amanda Singer, CS Edwin Lai, et al. “A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.Nat Biomed Eng 6, no. 6 (June 2022): 706–16. https://doi.org/10.1038/s41551-022-00873-7.
Chen JC, Kan P, Yu Z, Alrashdan F, Garcia R, Singer A, et al. A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves. Nat Biomed Eng. 2022 Jun;6(6):706–16.
Chen, Joshua C., et al. “A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.Nat Biomed Eng, vol. 6, no. 6, June 2022, pp. 706–16. Pubmed, doi:10.1038/s41551-022-00873-7.
Chen JC, Kan P, Yu Z, Alrashdan F, Garcia R, Singer A, Lai CSE, Avants B, Crosby S, Li Z, Wang B, Felicella MM, Robledo A, Peterchev AV, Goetz SM, Hartgerink JD, Sheth SA, Yang K, Robinson JT. A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves. Nat Biomed Eng. 2022 Jun;6(6):706–716.

Published In

Nat Biomed Eng

DOI

EISSN

2157-846X

Publication Date

June 2022

Volume

6

Issue

6

Start / End Page

706 / 716

Location

England

Related Subject Headings

  • Wireless Technology
  • Swine
  • Sciatic Nerve
  • Rats
  • Prostheses and Implants
  • Proof of Concept Study
  • Electric Power Supplies
  • Animals
  • 4003 Biomedical engineering