A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.

Journal Article (Journal Article)

Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals' sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.

Full Text

Duke Authors

Cited Authors

  • Chen, JC; Kan, P; Yu, Z; Alrashdan, F; Garcia, R; Singer, A; Lai, CSE; Avants, B; Crosby, S; Li, Z; Wang, B; Felicella, MM; Robledo, A; Peterchev, AV; Goetz, SM; Hartgerink, JD; Sheth, SA; Yang, K; Robinson, JT

Published Date

  • June 2022

Published In

Volume / Issue

  • 6 / 6

Start / End Page

  • 706 - 716

PubMed ID

  • 35361934

Pubmed Central ID

  • PMC9213237

Electronic International Standard Serial Number (EISSN)

  • 2157-846X

Digital Object Identifier (DOI)

  • 10.1038/s41551-022-00873-7


  • eng

Conference Location

  • England