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Increased Concentrations of Atherogenic Proteins in Aneurysm Sac Are Associated with Wall Enhancement of Unruptured Intracranial Aneurysm.

Publication ,  Journal Article
Ishii, D; Choi, A; Piscopo, A; Mehdi, Z; Raghuram, A; Zanaty, M; Lu, Y; Samaniego, EA; Hasan, DM
Published in: Transl Stroke Res
August 2022

Current MR-vessel wall imaging (VWI) of unruptured intracranial aneurysms (UIAs) permits the visualization of wall structures. Aneurysm wall enhancement (AWE) was associated with atherosclerotic remodeling of the aneurysm wall accompanied by infiltration of inflammatory cells, potentially contributing to rupture. This study sought to investigate whether the luminal concentrations of atherosclerotic proteins in the aneurysm sac were associated with increased wall enhancement of UIAs in VWI. Subjects undergoing endovascular treatment for UIAs were prospectively recruited. All subjects underwent evaluation using 3 T-MRI including pre/post contrast VWI of the UIAs. Blood samples were collected from the aneurysm sac and the parent artery during endovascular procedures. The presence of AWE was correlated with the delta difference in concentration between the aneurysm sac and the parent artery for each atherosclerotic protein. A total of consecutive 45 patients with 50 UIAs were enrolled. The delta differences of anti-oxidized low-density lipoprotein (LDL) antibody, small dense LDL, and lipoprotein(a) [Lp(a)] were significantly higher in UIAs with AWE compared with those without AWE (767.6 ± 1957.1 versus - 442.4 ± 1676.3 mIU/mL, p = 0.02, 114.8 ± 397.7 versus - 518.5 ± 1344.4 μg/mL, p = 0.04, and - 5.6 ± 11.3 versus - 28.7 ± 38.5 μg/mL, p = 0.01, respectively). In multivariate logistic regression analysis, the delta Lp(a) was significantly associated with AWE (p = 0.04). Increased concentrations of atherogenic proteins in the aneurysm sac were significantly associated with wall enhancement of UIAs. Future studies examining the effect of medications for atherosclerosis on the atherogenic proteins within the aneurysm sac and hence the wall enhancement are warranted.

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Published In

Transl Stroke Res

DOI

EISSN

1868-601X

Publication Date

August 2022

Volume

13

Issue

4

Start / End Page

577 / 582

Location

United States

Related Subject Headings

  • Magnetic Resonance Imaging
  • Intracranial Aneurysm
  • Humans
  • Cerebral Angiography
  • Atherosclerosis
  • 1117 Public Health and Health Services
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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MLA
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Ishii, D., Choi, A., Piscopo, A., Mehdi, Z., Raghuram, A., Zanaty, M., … Hasan, D. M. (2022). Increased Concentrations of Atherogenic Proteins in Aneurysm Sac Are Associated with Wall Enhancement of Unruptured Intracranial Aneurysm. Transl Stroke Res, 13(4), 577–582. https://doi.org/10.1007/s12975-021-00975-5
Ishii, Daizo, Alexander Choi, Anthony Piscopo, Zain Mehdi, Ashrita Raghuram, Mario Zanaty, Yongjun Lu, Edgar A. Samaniego, and David M. Hasan. “Increased Concentrations of Atherogenic Proteins in Aneurysm Sac Are Associated with Wall Enhancement of Unruptured Intracranial Aneurysm.Transl Stroke Res 13, no. 4 (August 2022): 577–82. https://doi.org/10.1007/s12975-021-00975-5.
Ishii D, Choi A, Piscopo A, Mehdi Z, Raghuram A, Zanaty M, et al. Increased Concentrations of Atherogenic Proteins in Aneurysm Sac Are Associated with Wall Enhancement of Unruptured Intracranial Aneurysm. Transl Stroke Res. 2022 Aug;13(4):577–82.
Ishii, Daizo, et al. “Increased Concentrations of Atherogenic Proteins in Aneurysm Sac Are Associated with Wall Enhancement of Unruptured Intracranial Aneurysm.Transl Stroke Res, vol. 13, no. 4, Aug. 2022, pp. 577–82. Pubmed, doi:10.1007/s12975-021-00975-5.
Ishii D, Choi A, Piscopo A, Mehdi Z, Raghuram A, Zanaty M, Lu Y, Samaniego EA, Hasan DM. Increased Concentrations of Atherogenic Proteins in Aneurysm Sac Are Associated with Wall Enhancement of Unruptured Intracranial Aneurysm. Transl Stroke Res. 2022 Aug;13(4):577–582.
Journal cover image

Published In

Transl Stroke Res

DOI

EISSN

1868-601X

Publication Date

August 2022

Volume

13

Issue

4

Start / End Page

577 / 582

Location

United States

Related Subject Headings

  • Magnetic Resonance Imaging
  • Intracranial Aneurysm
  • Humans
  • Cerebral Angiography
  • Atherosclerosis
  • 1117 Public Health and Health Services
  • 1109 Neurosciences
  • 1103 Clinical Sciences