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Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts.

Publication ,  Journal Article
Straube, TL; Farling, S; Deshusses, MA; Klitzman, B; Cheifetz, IM; Vesel, TP
Published in: Respir Care
April 2022

Acute respiratory failure with inadequate oxygenation and/or ventilation is a common reason for ICU admission in children and adults. Despite the morbidity and mortality associated with acute respiratory failure, few proven treatment options exist beyond invasive ventilation. Attempts to develop intravascular respiratory assist catheters capable of providing clinically important gas exchange have had limited success. Only one device, the IVOX catheter, was tested in human clinical trials before development was halted without FDA approval. Overcoming the technical challenges associated with providing safe and effective gas exchange within the confines of the intravascular space remains a daunting task for physicians and engineers. It requires a detailed understanding of the fundamentals of gas transport and respiratory physiology to optimize the design for a successful device. This article reviews the potential benefits of such respiratory assist catheters, considerations for device design, previous attempts at intravascular gas exchange, and the motivation for continued development efforts.

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Published In

Respir Care

DOI

EISSN

1943-3654

Publication Date

April 2022

Volume

67

Issue

4

Start / End Page

480 / 493

Location

United States

Related Subject Headings

  • Respiratory System
  • Respiratory Insufficiency
  • Respiratory Distress Syndrome
  • Respiration
  • Pulmonary Gas Exchange
  • Humans
  • Child
  • Carbon Dioxide
  • Adult
  • 3202 Clinical sciences
 

Citation

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Straube, T. L., Farling, S., Deshusses, M. A., Klitzman, B., Cheifetz, I. M., & Vesel, T. P. (2022). Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts. Respir Care, 67(4), 480–493. https://doi.org/10.4187/respcare.09288
Straube, Tobias L., Stewart Farling, Marc A. Deshusses, Bruce Klitzman, Ira M. Cheifetz, and Travis P. Vesel. “Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts.Respir Care 67, no. 4 (April 2022): 480–93. https://doi.org/10.4187/respcare.09288.
Straube TL, Farling S, Deshusses MA, Klitzman B, Cheifetz IM, Vesel TP. Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts. Respir Care. 2022 Apr;67(4):480–93.
Straube, Tobias L., et al. “Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts.Respir Care, vol. 67, no. 4, Apr. 2022, pp. 480–93. Pubmed, doi:10.4187/respcare.09288.
Straube TL, Farling S, Deshusses MA, Klitzman B, Cheifetz IM, Vesel TP. Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts. Respir Care. 2022 Apr;67(4):480–493.

Published In

Respir Care

DOI

EISSN

1943-3654

Publication Date

April 2022

Volume

67

Issue

4

Start / End Page

480 / 493

Location

United States

Related Subject Headings

  • Respiratory System
  • Respiratory Insufficiency
  • Respiratory Distress Syndrome
  • Respiration
  • Pulmonary Gas Exchange
  • Humans
  • Child
  • Carbon Dioxide
  • Adult
  • 3202 Clinical sciences