Intravascular Gas Exchange: Physiology, Literature Review, and Current Efforts.

Journal Article (Journal Article;Review)

Acute respiratory failure with inadequate oxygenation and/or ventilation is a common reason for ICU admission in children and adults. Despite the morbidity and mortality associated with acute respiratory failure, few proven treatment options exist beyond invasive ventilation. Attempts to develop intravascular respiratory assist catheters capable of providing clinically important gas exchange have had limited success. Only one device, the IVOX catheter, was tested in human clinical trials before development was halted without FDA approval. Overcoming the technical challenges associated with providing safe and effective gas exchange within the confines of the intravascular space remains a daunting task for physicians and engineers. It requires a detailed understanding of the fundamentals of gas transport and respiratory physiology to optimize the design for a successful device. This article reviews the potential benefits of such respiratory assist catheters, considerations for device design, previous attempts at intravascular gas exchange, and the motivation for continued development efforts.

Full Text

Duke Authors

Cited Authors

  • Straube, TL; Farling, S; Deshusses, MA; Klitzman, B; Cheifetz, IM; Vesel, TP

Published Date

  • April 2022

Published In

Volume / Issue

  • 67 / 4

Start / End Page

  • 480 - 493

PubMed ID

  • 35338096

Electronic International Standard Serial Number (EISSN)

  • 1943-3654

Digital Object Identifier (DOI)

  • 10.4187/respcare.09288


  • eng

Conference Location

  • United States