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Neural structure of a sensory decoder for motor control.

Publication ,  Journal Article
Egger, SW; Lisberger, SG
Published in: Nat Commun
April 5, 2022

The transformation of sensory input to motor output is often conceived as a decoder operating on neural representations. We seek a mechanistic understanding of sensory decoding by mimicking neural circuitry in the decoder's design. The results of a simple experiment shape our approach. Changing the size of a target for smooth pursuit eye movements changes the relationship between the variance and mean of the evoked behavior in a way that contradicts the regime of "signal-dependent noise" and defies traditional decoding approaches. A theoretical analysis leads us to propose a circuit for pursuit that includes multiple parallel pathways and multiple sources of variation. Behavioral and neural responses with biomimetic statistics emerge from a biologically-motivated circuit model with noise in the pathway that is dedicated to flexibly adjusting the strength of visual-motor transmission. Our results demonstrate the power of re-imagining decoding as processing through the parallel pathways of neural systems.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

April 5, 2022

Volume

13

Issue

1

Start / End Page

1829

Location

England

Related Subject Headings

  • Pursuit, Smooth
  • Photic Stimulation
  • Motion Perception
  • Macaca mulatta
  • Animals
 

Citation

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Egger, S. W., & Lisberger, S. G. (2022). Neural structure of a sensory decoder for motor control. Nat Commun, 13(1), 1829. https://doi.org/10.1038/s41467-022-29457-4
Egger, Seth W., and Stephen G. Lisberger. “Neural structure of a sensory decoder for motor control.Nat Commun 13, no. 1 (April 5, 2022): 1829. https://doi.org/10.1038/s41467-022-29457-4.
Egger SW, Lisberger SG. Neural structure of a sensory decoder for motor control. Nat Commun. 2022 Apr 5;13(1):1829.
Egger, Seth W., and Stephen G. Lisberger. “Neural structure of a sensory decoder for motor control.Nat Commun, vol. 13, no. 1, Apr. 2022, p. 1829. Pubmed, doi:10.1038/s41467-022-29457-4.
Egger SW, Lisberger SG. Neural structure of a sensory decoder for motor control. Nat Commun. 2022 Apr 5;13(1):1829.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

April 5, 2022

Volume

13

Issue

1

Start / End Page

1829

Location

England

Related Subject Headings

  • Pursuit, Smooth
  • Photic Stimulation
  • Motion Perception
  • Macaca mulatta
  • Animals