Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease.

Journal Article (Journal Article;Review)

Recent investigations have expanded our knowledge of the regulatory bone marrow (BM) niche, which is critical in maintaining and directing hematopoietic stem cell (HSC) self-renewal and differentiation. Osteoblasts, mesenchymal stem cells (MSCs), and CXCL12-abundant reticular (CAR) cells are niche components in close association with HSCs and have been more clearly defined in immune cell function and homeostasis. Importantly, cellular inhabitants of the BM niche signal through G protein-coupled surface receptors (GPCRs) for various appropriate immune functions. In this article, recent literature on BM niche inhabitants (HSCs, osteoblasts, MSCs, CAR cells) and their GPCR mechanistic interactions are reviewed for better understanding of the BM cells involved in immune development, immunologic disease, and current immune reconstitution therapies.

Full Text

Duke Authors

Cited Authors

  • Brozowski, JM; Billard, MJ; Tarrant, TK

Published Date

  • February 2014

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • 402 -

PubMed ID

  • 24408534

Pubmed Central ID

  • PMC3932436

Electronic International Standard Serial Number (EISSN)

  • 1534-6315

Digital Object Identifier (DOI)

  • 10.1007/s11882-013-0402-8

Language

  • eng

Conference Location

  • United States