S100A9 is not essential for disease expression in an acute (K/BxN) or chronic (CIA) model of inflammatory arthritis.

Journal Article (Journal Article)

Objective

S100A8 (calgranulin A, MRP8) and S100A9 (calgranulin B, MRP14) are calcium-binding proteins highly expressed by activated myeloid cells and thought to be involved in the pathogenesis of inflammatory diseases. Circulating levels of S100A8/S100A9 are elevated in both human and experimental models of autoimmune disease, including rheumatoid arthritis (RA).

Methods

Mice deficient in S100A9 (S100A9 - /-) and wild-type controls were immunized using standard techniques for the K/BxN serum transfer or the collagen-induced arthritis (CIA) model.

Results

S100A9 - /- animals, with defective expression of both S100A8 and S100A9 proteins, had similar arthritis and histopathology to that of wild-type controls in both mouse models.

Conclusion

S100A8 and S100A9 are not essential for disease expression in either the K/BxN serum transfer or the CIA model of inflammatory arthritis.

Full Text

Duke Authors

Cited Authors

  • Rampersad, RR; Esserman, D; McGinnis, MW; Lee, DM; Patel, DD; Tarrant, TK

Published Date

  • November 2009

Published In

Volume / Issue

  • 38 / 6

Start / End Page

  • 445 - 449

PubMed ID

  • 19922019

Pubmed Central ID

  • PMC2866179

Electronic International Standard Serial Number (EISSN)

  • 1502-7732

International Standard Serial Number (ISSN)

  • 0300-9742

Digital Object Identifier (DOI)

  • 10.3109/03009740902895743

Language

  • eng