A 24-hour comparison of serum growth hormone concentrations in patients with heart failure versus healthy controls.

Journal Article (Journal Article)

STUDY OBJECTIVE: To compare endogenous serum growth hormone concentrations over a 24-hour period in patients with chronic heart failure (CHF) and matched controls. DESIGN: Prospective, 24-hour, endogenous concentration comparison. SETTING: Hospital research center. PATIENTS: Eight evaluable patients with nonischemic dilated cardiomyopathy and 10 healthy control subjects, matched for age and sex. INTERVENTION: Over a 24-hour period, blood was drawn from the study participants every 20 minutes for determination of growth hormone. MEASUREMENTS AND MAIN RESULTS: For each patient, the area under the concentration-time curve from time 0-24 hours (AUC0-24), maximum concentration (Cmax), and minimum concentration (Cnadir) of growth hormone were determined. The AUC0-24 and Cmax were 74% (p < 0.05) and 62% (p < 0.05) lower in patients with CHF than in controls, respectively. The Cnadir for all participants was 0 microg/L. Variability in growth hormone concentrations over the 24 hours was considerable for all study participants. CONCLUSIONS: Growth hormone concentrations are suppressed over a 24-hour period in patients with CHF versus healthy controls. Variability in levels throughout the day suggests that a single point evaluation cannot be used to determine deficiency or abundance of growth hormone.

Full Text

Duke Authors

Cited Authors

  • Duncan, B; Moyna, NM; Heller, GV; McGill, C; Katten, D; Finta, L; Velusamy, M; Kelsey, A; Wieczorek, S; Wu, AHB; White, CM

Published Date

  • February 2003

Published In

Volume / Issue

  • 23 / 2

Start / End Page

  • 147 - 152

PubMed ID

  • 12587802

International Standard Serial Number (ISSN)

  • 0277-0008

Digital Object Identifier (DOI)

  • 10.1592/phco.23.2.147.32093

Language

  • eng

Conference Location

  • United States