Human genetic admixture through the lens of population genomics.

Journal Article (Review;Journal Article)

Over the past 50 years, geneticists have made great strides in understanding how our species' evolutionary history gave rise to current patterns of human genetic diversity classically summarized by Lewontin in his 1972 paper, 'The Apportionment of Human Diversity'. One evolutionary process that requires special attention in both population genetics and statistical genetics is admixture: gene flow between two or more previously separated source populations to form a new admixed population. The admixture process introduces ancestry-based structure into patterns of genetic variation within and between populations, which in turn influences the inference of demographic histories, identification of genetic targets of selection and prediction of complex traits. In this review, we outline some challenges for admixture population genetics, including limitations of applying methods designed for populations without recent admixture to the study of admixed populations. We highlight recent studies and methodological advances that aim to overcome such challenges, leveraging genomic signatures of admixture that occurred in the past tens of generations to gain insights into human history, natural selection and complex trait architecture. This article is part of the theme issue 'Celebrating 50 years since Lewontin's apportionment of human diversity'.

Full Text

Duke Authors

Cited Authors

  • Gopalan, S; Smith, SP; Korunes, K; Hamid, I; Ramachandran, S; Goldberg, A

Published Date

  • June 2022

Published In

Volume / Issue

  • 377 / 1852

Start / End Page

  • 20200410 -

PubMed ID

  • 35430881

Pubmed Central ID

  • PMC9014191

Electronic International Standard Serial Number (EISSN)

  • 1471-2970

International Standard Serial Number (ISSN)

  • 0962-8436

Digital Object Identifier (DOI)

  • 10.1098/rstb.2020.0410

Language

  • eng