Interaction of Vitamin D and Corticosteroid Use in Hospitalized COVID-19 Patients: A Potential Explanation for Inconsistent Findings in the Literature.

Journal Article (Journal Article)

Vitamin D is an important immune-modulator with anti-inflammatory properties. While this prohormone has been studied extensively in the prevention and treatment of COVID-19, findings have been inconsistent regarding its overall benefit in patients hospitalized with COVID-19. Most studies to date have been observational in nature, not accounting for the use of corticosteroids. Furthermore, the few randomized clinical trials designed to examine the effect of vitamin D supplementation on COVID-19 outcomes have been relatively small and thus insufficiently powered to assure a balance of corticosteroid use between study arms. The current perspective addresses the interaction of vitamin D and corticosteroids as a potential explanation for the divergent results reported in the literature. Future research on vitamin D and COVID-19 will benefit by considering this interaction, especially among hospitalized patients requiring oxygen and mechanical ventilation.

Full Text

Duke Authors

Cited Authors

  • Efird, JT; Anderson, EJ; Jindal, C; Suzuki, A

Published Date

  • 2022

Published In

Volume / Issue

  • 28 / 21

Start / End Page

  • 1695 - 1702

PubMed ID

  • 35440302

Electronic International Standard Serial Number (EISSN)

  • 1873-4286

Digital Object Identifier (DOI)

  • 10.2174/1381612828666220418132847


  • eng

Conference Location

  • United Arab Emirates