Recent Advances in 1,2-Amino(hetero)arylation of Alkenes.

Journal Article (Review;Journal Article)

Alkene amino(hetero)arylation presents a highly efficient and straightforward strategy for direct installation of amino groups and heteroaryl rings across a double bond simultaneously. An extensive array of practical transformations has been developed via alkene difunctionalization approach to access a broad range of medicinally valuable (hetero)arylethylamine motifs. This review presents recent progress in 1,2-amino(hetero)arylation of alkenes organized in three different modes. First, intramolecular transformations employing C, N-tethered alkenes will be introduced. Next, two-component reactions will be discussed with different combination of precursors, N-tethered alkenes and external aryl precursor, C-tethered alkenes and external amine precursor, or C, N-tethered reagents, and alkenes. Last, three-component intermolecular amino(hetero)arylation reactions will be covered.

Full Text

Duke Authors

Cited Authors

  • Kwon, Y; Wang, Q

Published Date

  • June 2022

Published In

Volume / Issue

  • 17 / 12

Start / End Page

  • e202200215 -

PubMed ID

  • 35460596

Pubmed Central ID

  • PMC9357224

Electronic International Standard Serial Number (EISSN)

  • 1861-471X

International Standard Serial Number (ISSN)

  • 1861-4728

Digital Object Identifier (DOI)

  • 10.1002/asia.202200215


  • eng