Benefits from disease-burden reduction for type 2 diabetes and obesity through comprehensive regulatory restrictions on phthalate use in China

Journal Article (Journal Article)

Evidence is accumulating that the increasing incidence of type 2 diabetes and obesity is correlated with exposure to certain phthalates, which brings growing concern to the public health of China. However, the extent to which phthalate restrictions will alleviate these health concerns remains unclear. Here, we employed a sequential modeling approach to evaluate the impact that a series of restrictions would have on the mass of phthalates in the use phase, indoor concentrations, exposure, and the attributable disease burden of type 2 diabetes and obesity in adults. We show that, compared with the business-as-usual scenario, the implementation of the strongest restriction on the concerned phthalates in 2016 can decrease the use of phthalates by up to 91.2%, indoor airborne phthalate concentrations by 93.8%, and indoor dust-phase phthalate concentrations by 90.2% by 2031. Correspondingly, the decrease in phthalate exposure would result in a health benefit of 134.6 billion CNY. These findings call for the urgent need to restrict the use of certain phthalates to reduce the burden of type 2 diabetes and obesity in China.

Full Text

Duke Authors

Cited Authors

  • Shi, S; Zhang, J; Gong, J; Zhao, B

Published Date

  • April 15, 2022

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 380 - 391

Electronic International Standard Serial Number (EISSN)

  • 2590-3322

International Standard Serial Number (ISSN)

  • 2590-3330

Digital Object Identifier (DOI)

  • 10.1016/j.oneear.2022.03.013

Citation Source

  • Scopus