Tourette's syndrome and autism: A search for common ground

Journal Article (Review;Journal)

The comorbidity between autistic spectrum disorders and Tourette's syndrome (TS) raises intriguing questions about the neurobiology of both disorders. Repetitive movements, stereotypies, echophenomena, self-injurious behaviors and compulsive behaviors are common in autistic spectrum, and a subset of severe TS without autism. The appearance of this symptom in individuals with severe intellectual disabilities presents problems in differential diagnosis. This overlap also extends to treatment in which both developmental disorders respond to low doses of serotonin reuptake inhibitors and atypical antipsychotics drugs and display a narrow therapeutic index for these agents. These similarities suggest an overlapping fronto-stiatal substrate for at least some forms of autistic spectrum disorders and complex movement disorders like TS.

Duke Authors

Cited Authors

  • Barnhill, J; Horrigan, JP

Published Date

  • March 14, 2002

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 7 - 15

International Standard Serial Number (ISSN)

  • 1057-3291

Citation Source

  • Scopus