Guanfacine and secondary mania in children.

Journal Article (Journal Article)

INTRODUCTION: Guanfacine hydrochloride is an alpha-2 adrenergic agonist, which has gained recent attention in the field of child and adolescent psychiatry. This medication has been described as effective in the management of attention-deficit hyperactivity and tic disorders, with minimal side effects. METHODS: Presented here are five cases of behavioral activation in children treated with guanfacine. RESULTS: In each instance the clinical presentation resembled an acute hypomanic or manic episode. The dose of guanfacine was 0.5 mg/day. Later investigation revealed that all of the youngsters had clear risk factors (clinical and/or familial) for bipolar disorder. CONCLUSIONS: It appears as though guanfacine may be capable of precipitating secondary mania in vulnerable children.

Full Text

Duke Authors

Cited Authors

  • Horrigan, JP; Barnhill, LJ

Published Date

  • August 1999

Published In

Volume / Issue

  • 54 / 3

Start / End Page

  • 309 - 314

PubMed ID

  • 10467976

International Standard Serial Number (ISSN)

  • 0165-0327

Digital Object Identifier (DOI)

  • 10.1016/s0165-0327(98)00183-9


  • eng

Conference Location

  • Netherlands