Glioma grading using structural magnetic resonance imaging and molecular data.

Journal Article (Journal Article)

A glioma grading method using conventional structural magnetic resonance image (MRI) and molecular data from patients is proposed. The noninvasive grading of glioma tumors is obtained using multiple radiomic texture features including dynamic texture analysis, multifractal detrended fluctuation analysis, and multiresolution fractal Brownian motion in structural MRI. The proposed method is evaluated using two multicenter MRI datasets: (1) the brain tumor segmentation (BRATS-2017) challenge for high-grade versus low-grade (LG) and (2) the cancer imaging archive (TCIA) repository for glioblastoma (GBM) versus LG glioma grading. The grading performance using MRI is compared with that of digital pathology (DP) images in the cancer genome atlas (TCGA) data repository. The results show that the mean area under the receiver operating characteristic curve (AUC) is 0.88 for the BRATS dataset. The classification of tumor grades using MRI and DP images in TCIA/TCGA yields mean AUC of 0.90 and 0.93, respectively. This work further proposes and compares tumor grading performance using molecular alterations (IDH1/2 mutations) along with MRI and DP data, following the most recent World Health Organization grading criteria, respectively. The overall grading performance demonstrates the efficacy of the proposed noninvasive glioma grading approach using structural MRI.

Full Text

Duke Authors

Cited Authors

  • Reza, SMS; Samad, MD; Shboul, ZA; Jones, KA; Iftekharuddin, KM

Published Date

  • April 2019

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 024501 -

PubMed ID

  • 31037246

Pubmed Central ID

  • PMC6479231

International Standard Serial Number (ISSN)

  • 2329-4302

Digital Object Identifier (DOI)

  • 10.1117/1.JMI.6.2.024501

Language

  • eng

Conference Location

  • United States