Predictors of Self-repackaging of Antiretroviral Therapy in Northern Tanzania.

Journal Article (Journal Article)

Objectives: In this study, we explored determinants of "researcher-observed" patient-initiated antiretroviral therapy (ART) repackaging practices among people living with HIV (PLHIV) in Northern Tanzania. Methods: We used a quasi-experimental design to describe the prevalence of ART self- repackaging; we conducted face-to-face surveys to determine factors associated with ART self- repackaging practices. Data collection sites included the Kilimanjaro Christian Medical Centre and the Mawenzi Referral Hospital. We used study-specific numerical identifiers assigned to ARTs packaging to determine self-repackaging behavior. Self-repackaging was defined as a binary variable where participants who discarded antiretroviral drugs packaging in at least 2 clinic visits were classified as self- repackagers. We used multivariable logistic regression to assess the determinants of patient-initiated repackaging practices. Results: Among 590 study participants, 57.6% self-repackaged based on researcher observation and 55.6% self-repackaged based on patient report. Researcher-observed self- repackaging was associated with gender (AOR = 1.590; 95% CI: 1.011, 2.502), employment status (AOR = 0.475: 95% CI; 0.239, 0.942), and study site (AOR = 0.218; 95% CI: 0.134, 0.355). Conclusions: A substantial proportion of patients self-repackage their ARTs for various reasons. Health system interventions should focus on addressing the attributes of repackaging among men and unemployed patients.

Full Text

Duke Authors

Cited Authors

  • Semvua, SK; Kim, CY; Muiruri, C; Peter, TA; Mmbaga, BT; Bartlett, JA; Zullig, LL; Jazowski, SA; Knettel, BA; Karia, FP; Ramadhani, HO

Published Date

  • April 20, 2022

Published In

Volume / Issue

  • 46 / 2

Start / End Page

  • 124 - 133

PubMed ID

  • 35501963

Pubmed Central ID

  • PMC9300215

Electronic International Standard Serial Number (EISSN)

  • 1945-7359

Digital Object Identifier (DOI)

  • 10.5993/AJHB.46.2.3

Language

  • eng

Conference Location

  • England