Plasmodium's fight for survival: escaping elimination while acquiring nutrients.

Journal Article (Review;Journal Article)

Plasmodium parasites extensively alter their host hepatocyte to evade host detection and support an unprecedented replication rate. Host cell manipulation includes association with the host early and late endomembrane systems, where Plasmodium accesses nutrients while suppressing cellular immune processes. Early endomembrane organelles provide an opportunity to sequester an abundance of lipids and proteins, but the association with late endomembrane organelles also risks autophagy-mediated elimination. While not all parasites survive, those that do benefit from a plethora of nutrients provided through this pathway. In this review, we discuss recent advances in our understanding of how Plasmodium parasites balance the need for host nutrients while avoiding elimination during the liver stage.

Full Text

Duke Authors

Cited Authors

  • Schroeder, EA; Chirgwin, ME; Derbyshire, ER

Published Date

  • July 2022

Published In

Volume / Issue

  • 38 / 7

Start / End Page

  • 544 - 557

PubMed ID

  • 35534377

Pubmed Central ID

  • PMC9187605

Electronic International Standard Serial Number (EISSN)

  • 1471-5007

International Standard Serial Number (ISSN)

  • 1471-4922

Digital Object Identifier (DOI)

  • 10.1016/j.pt.2022.04.004

Language

  • eng