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The origins and roles of osteoclasts in bone development, homeostasis and repair.

Publication ,  Journal Article
Yahara, Y; Nguyen, T; Ishikawa, K; Kamei, K; Alman, BA
Published in: Development
April 15, 2022

The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte lineage cells with resorptive abilities, forming the bone marrow cavity during development. This marrow cavity, essential to hematopoiesis and osteoclast-osteoblast interactions, provides a setting to investigate the origin of osteoclasts and their multi-faceted roles. This Review examines recent developments in the embryonic understanding of osteoclast origin, as well as interactions within the immune environment to regulate normal and pathological bone development, homeostasis and repair.

Duke Scholars

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Published In

Development

DOI

EISSN

1477-9129

Publication Date

April 15, 2022

Volume

149

Issue

8

Location

England

Related Subject Headings

  • Osteoclasts
  • Humans
  • Homeostasis
  • Cell Differentiation
  • Bone Resorption
  • Bone Development
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

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Yahara, Y., Nguyen, T., Ishikawa, K., Kamei, K., & Alman, B. A. (2022). The origins and roles of osteoclasts in bone development, homeostasis and repair. Development, 149(8). https://doi.org/10.1242/dev.199908
Yahara, Yasuhito, Tuyet Nguyen, Koji Ishikawa, Katsuhiko Kamei, and Benjamin A. Alman. “The origins and roles of osteoclasts in bone development, homeostasis and repair.Development 149, no. 8 (April 15, 2022). https://doi.org/10.1242/dev.199908.
Yahara Y, Nguyen T, Ishikawa K, Kamei K, Alman BA. The origins and roles of osteoclasts in bone development, homeostasis and repair. Development. 2022 Apr 15;149(8).
Yahara, Yasuhito, et al. “The origins and roles of osteoclasts in bone development, homeostasis and repair.Development, vol. 149, no. 8, Apr. 2022. Pubmed, doi:10.1242/dev.199908.
Yahara Y, Nguyen T, Ishikawa K, Kamei K, Alman BA. The origins and roles of osteoclasts in bone development, homeostasis and repair. Development. 2022 Apr 15;149(8).
Journal cover image

Published In

Development

DOI

EISSN

1477-9129

Publication Date

April 15, 2022

Volume

149

Issue

8

Location

England

Related Subject Headings

  • Osteoclasts
  • Humans
  • Homeostasis
  • Cell Differentiation
  • Bone Resorption
  • Bone Development
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences