The origins and roles of osteoclasts in bone development, homeostasis and repair.

Journal Article (Journal Article;Review)

The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte lineage cells with resorptive abilities, forming the bone marrow cavity during development. This marrow cavity, essential to hematopoiesis and osteoclast-osteoblast interactions, provides a setting to investigate the origin of osteoclasts and their multi-faceted roles. This Review examines recent developments in the embryonic understanding of osteoclast origin, as well as interactions within the immune environment to regulate normal and pathological bone development, homeostasis and repair.

Full Text

Duke Authors

Cited Authors

  • Yahara, Y; Nguyen, T; Ishikawa, K; Kamei, K; Alman, BA

Published Date

  • April 15, 2022

Published In

Volume / Issue

  • 149 / 8

PubMed ID

  • 35502779

Pubmed Central ID

  • PMC9124578

Electronic International Standard Serial Number (EISSN)

  • 1477-9129

Digital Object Identifier (DOI)

  • 10.1242/dev.199908


  • eng

Conference Location

  • England