Laser-Assisted Delivery of Topical Cidofovir in the Treatment of Plantar Warts.
Recalcitrant plantar warts pose a therapeutic challenge. Cidofovir is a viral DNA polymerase inhibitor that has been used in treatment of verrucae with greater success than traditional treatments in some cases. Laser-assisted drug delivery enhances drug penetration beyond the epidermis and is particularly well-suited, though under-utilized, to target palmoplantar verrucae. We report the use of an erbium:yttrium-aluminum-garnet (Er:YAG) ablative fractional laser (AFL) followed by topical cidofovir in treating recalcitrant plantar warts. Two patients were treated with a 2940-nm Er:YAG laser at depths of 1.2-1.5 mm followed by topical application of cidofovir 75 mg/mL. Both patients exhibited a significant reduction in lesion size and improvement in symptoms. AFL-assisted delivery of topical cidofovir represents a promising therapeutic option for recalcitrant plantar warts. J Drugs Dermatol. 2019;18(7):663-665.
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- Warts
- Treatment Outcome
- Solutions
- Skin Absorption
- Middle Aged
- Male
- Lasers, Solid-State
- Humans
- Foot Dermatoses
- Drug Delivery Systems
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Warts
- Treatment Outcome
- Solutions
- Skin Absorption
- Middle Aged
- Male
- Lasers, Solid-State
- Humans
- Foot Dermatoses
- Drug Delivery Systems