Laser-Assisted Delivery of Topical Cidofovir in the Treatment of Plantar Warts

Journal Article (Journal Article)

Recalcitrant plantar warts pose a therapeutic challenge. Cidofovir is a viral DNA polymerase inhibitor that has been used in treatment of verrucae with greater success than traditional treatments in some cases. Laser-assisted drug delivery enhances drug penetration beyond the epidermis and is particularly well-suited, though under-utilized, to target palmoplantar verrucae. We report the use of an erbium:yttrium-aluminum-garnet (Er:YAG) ablative fractional laser (AFL) followed by topical cidofovir in treating recalcitrant plantar warts. Two patients were treated with a 2940-nm Er:YAG laser at depths of 1.2-1.5 mm followed by topical application of cidofovir 75 mg/mL. Both patients exhibited a significant reduction in lesion size and improvement in symptoms. AFL-assisted delivery of topical cidofovir represents a promising therapeutic option for recalcitrant plantar warts. J Drugs Dermatol. 2019;18(7):663-665.

Full Text

Duke Authors

Cited Authors

  • Coates, M; Patel, J; Powers, C; Burton, C

Published Date

  • July 1, 2019

Published In

Volume / Issue

  • 18 / 7

Start / End Page

  • 663 - 665

PubMed ID

  • 31334626

International Standard Serial Number (ISSN)

  • 1545-9616

Language

  • eng

Conference Location

  • United States