Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation.

Journal Article (Journal Article)

Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to date. Polypodium leucotomos exerts a pleiotropic immunomodulatory and antioxidant effect by shifting the balance from pro- to an antiinflammatory cytokine environment. This counteracts the effects of UV-induced cellular damage characteristic of photodermatoses.

Full Text

Duke Authors

Cited Authors

  • Stump, M; Dhinsa, H; Powers, J; Stone, M

Published Date

  • January 2022

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 145 - 146

PubMed ID

  • 34888940

Electronic International Standard Serial Number (EISSN)

  • 1525-1470

Digital Object Identifier (DOI)

  • 10.1111/pde.14876


  • eng

Conference Location

  • United States