Acquired idiopathic generalized anhidrosis: A case series of two Caucasian patients.

Journal Article

Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder characterized by insidious or sudden onset of the inability to sweat involving >25% of body surface area in the absence of other neurologic or sweat gland abnormalities and typically affects young, healthy, Asian men. Here, we describe two Caucasian teenagers with the diagnosis. They both had variable responses to prednisone, one in the setting of an elevated ANA, suggesting an autoimmune or inflammatory pathomechanism of the disorder. It is essential the clinician recognizes this rare entity and initiates timely intervention to prevent the serious consequences of hyperpyrexia.

Full Text

Duke Authors

Cited Authors

  • Reid, AT; Goettsche, L; Willis, M; Powers, J; Berrebi, KG

Published Date

  • September 2021

Published In

Volume / Issue

  • 38 / 5

Start / End Page

  • 1219 - 1221

PubMed ID

  • 34398994

Electronic International Standard Serial Number (EISSN)

  • 1525-1470

Digital Object Identifier (DOI)

  • 10.1111/pde.14694


  • eng

Conference Location

  • United States