Recent advances on the inhibition of human solute carriers: Therapeutic implications and mechanistic insights.

Journal Article (Journal Article;Review)

Solute carriers (SLCs) are membrane transport proteins tasked with mediating passage of hydrophilic molecules across lipid bilayers. Despite the extensive roles played in all aspects of human biology, SLCs remain vastly under-explored as therapeutic targets. In this brief review, we first discuss a few successful cases of drugs that exert their mechanisms of action through inhibition of human SLCs, and introduce select examples of human SLCs that have untapped therapeutic potential. We then highlight two recent structural studies which uncovered detailed structural mechanisms of inhibition exhibited against two different human major facilitator superfamily (MFS) transporters of clinical relevance.

Full Text

Duke Authors

Cited Authors

  • Wright, NJ; Lee, S-Y

Published Date

  • June 2022

Published In

Volume / Issue

  • 74 /

Start / End Page

  • 102378 -

PubMed ID

  • 35487145

Electronic International Standard Serial Number (EISSN)

  • 1879-033X

Digital Object Identifier (DOI)

  • 10.1016/j.sbi.2022.102378

Language

  • eng

Conference Location

  • England