Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal Article (Letter;Multicenter Study)

A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

Full Text

Duke Authors

Cited Authors

  • Newman, JD; Douglas, PS; Zhbannikov, I; Ferencik, M; Foldyna, B; Hoffmann, U; Shah, SH; Ginsburg, GS; Lu, MT; Voora, D

Published Date

  • October 2022

Published In

Volume / Issue

  • 252 /

Start / End Page

  • 12 - 15

PubMed ID

  • 35605652

Pubmed Central ID

  • PMC9336199

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2022.05.012


  • eng

Conference Location

  • United States