Skip to main content

The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.

Publication ,  Journal Article
Laptook, AR; Chalak, L; Pappas, A; Davis, A; Sanchez, PJ; Van Meurs, KP; Oh, W; Sommers, R; Shankaran, S; Hensman, AM; Rouse, DJ; McDonald, S ...
Published in: J Perinatol
December 2022

OBJECTIVE: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. STUDY DESIGN: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 340-356 weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity. RESULTS: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage. CONCLUSIONS: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

December 2022

Volume

42

Issue

12

Start / End Page

1615 / 1621

Location

United States

Related Subject Headings

  • Premature Birth
  • Pregnancy
  • Pediatrics
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Female
  • Electroencephalography
  • Cohort Studies
  • Betamethasone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Laptook, A. R., Chalak, L., Pappas, A., Davis, A., Sanchez, P. J., Van Meurs, K. P., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network, . (2022). The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation. J Perinatol, 42(12), 1615–1621. https://doi.org/10.1038/s41372-022-01415-4
Laptook, Abbot R., Lina Chalak, Athina Pappas, Alexis Davis, Pablo J. Sanchez, Krisa P. Van Meurs, William Oh, et al. “The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.J Perinatol 42, no. 12 (December 2022): 1615–21. https://doi.org/10.1038/s41372-022-01415-4.
Laptook AR, Chalak L, Pappas A, Davis A, Sanchez PJ, Van Meurs KP, et al. The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation. J Perinatol. 2022 Dec;42(12):1615–21.
Laptook, Abbot R., et al. “The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.J Perinatol, vol. 42, no. 12, Dec. 2022, pp. 1615–21. Pubmed, doi:10.1038/s41372-022-01415-4.
Laptook AR, Chalak L, Pappas A, Davis A, Sanchez PJ, Van Meurs KP, Oh W, Sommers R, Shankaran S, Hensman AM, Rouse DJ, McDonald S, Das A, Goldberg RN, Ambalavanan N, Gyamfi-Bannerman C, Thom EA, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN), Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation. J Perinatol. 2022 Dec;42(12):1615–1621.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

December 2022

Volume

42

Issue

12

Start / End Page

1615 / 1621

Location

United States

Related Subject Headings

  • Premature Birth
  • Pregnancy
  • Pediatrics
  • Infant, Newborn
  • Humans
  • Gestational Age
  • Female
  • Electroencephalography
  • Cohort Studies
  • Betamethasone