Acute Decompensated Heart Failure in the Setting of Acute Coronary Syndrome.

Journal Article (Journal Article;Review)

Acute coronary syndrome (ACS) is frequently complicated by evidence of heart failure (HF). Those at highest risk for acute decompensated HF in the setting of ACS (ACS-HF) are older, female, and have preexisting heart disease, type 2 diabetes mellitus, hypertension, and/or kidney disease. The presence of ACS-HF is strongly associated with higher mortality and more frequent readmissions, especially for HF. Low implementation of guideline-directed medical therapy has further complicated the clinical care of this high-risk population. Improved utilization of current therapies, coupled with further investigation of strategies to manage ACS-HF, is desperately needed to improve outcomes in this vulnerable population, and the results of currently ongoing or recently concluded ACS-HF studies in this population are of great interest. In this review, we explore the pathophysiology, epidemiology, risk factors, and outcomes for patients with ACS-HF, and describe both existing evidence for management of this challenging condition and areas requiring further research.

Full Text

Duke Authors

Cited Authors

  • Harrington, J; Jones, WS; Udell, JA; Hannan, K; Bhatt, DL; Anker, SD; Petrie, MC; Vedin, O; Butler, J; Hernandez, AF

Published Date

  • June 2022

Published In

Volume / Issue

  • 10 / 6

Start / End Page

  • 404 - 414

PubMed ID

  • 35654525

Electronic International Standard Serial Number (EISSN)

  • 2213-1787

Digital Object Identifier (DOI)

  • 10.1016/j.jchf.2022.02.008


  • eng

Conference Location

  • United States