Pyrrolidine-Oxadiazolone Conjugates as Organocatalysts in Asymmetric Michael Reaction.

Journal Article (Journal Article)

Pyrrolidine-oxadiazolone based organocatalysts are envisaged, synthesized, and utilized for asymmetric Michael reactions. Results of the investigations suggest that some of the catalysts are indeed efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to 99%) in high chemical yields (up to 97%) often in short reaction time. As an extension, one enantiopure Michael adduct has been utilized to synthesize optically active octahydroindole.

Full Text

Duke Authors

Cited Authors

  • Mahato, CK; Mukherjee, S; Kundu, M; Pramanik, A

Published Date

  • January 2019

Published In

Volume / Issue

  • 84 / 2

Start / End Page

  • 1053 - 1063

PubMed ID

  • 30577689

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/acs.joc.8b02393

Language

  • eng