Copper Catalyzed C-N Cross-Coupling Reaction of Aryl Boronic Acids at Room Temperature through Chelation Assistance.

Journal Article (Journal Article)

A copper-catalyzed selective C-N cross-coupling has been developed based on chelation-assisted amidation of readily available aryl boronic acids at room-temperature under open-flask conditions. The reaction is scalable and tolerates a wide spectrum of functional groups delivering fully substituted unsymmetrical amides in high yields (up to 96%). The C-N cross coupling also established with aryl silanes, extending the palette of coupling partners of this strategy.

Full Text

Duke Authors

Cited Authors

  • Sahoo, H; Mukherjee, S; Grandhi, GS; Selvakumar, J; Baidya, M

Published Date

  • March 2017

Published In

Volume / Issue

  • 82 / 5

Start / End Page

  • 2764 - 2771

PubMed ID

  • 28186417

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/acs.joc.7b00002

Language

  • eng